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Prediction, which aims to construct the correct protein 3D model from amino acid QUARK is a computer algorithm for ab initio protein folding and protein structure Bell, Yang Zhangįolding non-homology proteins by coupling deep-learning contact maps with I-TASSER assembly simulations. Wei Zheng, Chengxin Zhang, Yang Li, Robin Pearce, Eric W. Protein structure and function predictions.īy integrating deep-learning contact-maps, C-I-TASSER provides moreĪccurate structure predictions than I-TASSER,Įspecially for the targets that lack homologous templates in the PDB.

I-TASSER-MTD: A deep-learning based platform for multi-domain protein structure and function prediction, Nature Protocols, in press, 2022.Ĭ-I-TASSER server is an extension of I-TASSER for contact-assisted Xiaogen Zhou, Wei Zheng, Yang Li, Robin Pearce, Chengxin Zhang, Eric W. Meanwhile, the protein functions at both domain level and full-chain level areĪnnotated by COFACTOR based on structures, sequences, and protein-protein interaction networks. Under guidance of quaternary structural templates and deep-learning distance profiles. The individual domain models are assembled into full-length structure by DEMO I-TASSER guided by the deep learning predicted spatial restraints. Next, the structure model of each individual domain is constructed independently by I-TASSER-MTD is multi-domain version of I-TASSER.įor a given sequence, it first predicts the domain boundaries by FUpred and ThreaDomīased on the deep-learning contact-map prediction and multiple threading alignments. I-TASSER server for protein 3D structure prediction. I-TASSER: a unified platform for automated protein structure and function prediction.

Ambrish Roy, Alper Kucukural, Yang Zhang.The goal to provide accurate structural and function predictions using I-TASSER (as 'Zhang-Server') was ranked as the No 1 server Models are built based on multiple-threading alignments by LOMETS and iterative I-TASSER server is an Internet service for protein structure and function predictions.

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